منابع مشابه
Deoxyribose5-phosphate metabolism by normal liver and malignant hepatoma.
The requirement for net synthesis of deoxyribonucleic acid in a growing tissue, normal or malignant, is well established. The synthetic pathways of the purine and pyrimidine moieties of nucleic acids have been largely elucidated, but most of the available data are concerned with ribonucleic acid synthesis. The metabolic origin of the deoxyribose moiety of DNA1 is, however, not clearly establish...
متن کاملAntisense downregulation of N-myc1 in woodchuck hepatoma cells reverses the malignant phenotype.
Cell line WH44KA is a highly malignant woodchuck hepatoma cell line. WH44KA cells contain a single woodchuck hepatitis virus (WHV) DNA integration in the 3' untranslated region of exon 3 of the woodchuck N-myc1 gene. The highly rearranged WHV DNA contains WHV enhancers which activate the N-myc promoter, and a hybrid N-myc1-WHV mRNA is produced, which leads to a high steady-state level of N-myc1...
متن کاملActivities and isoenzyme patterns of some enzymes of glucose metabolism in human primary malignant hepatoma.
The levels of a number of enzymes of carbohydrate metabolism were assayed in the cancerous and morphologically normal (host) portions of livers from nine primary malignant hepatoma cases obtained at autopsy. The levels of these enzymes in two normal human adult and two fetal livers were also determined. The activities of phosphoglucomutase, fructose 1,6-diphosphatase and a-glycerophosphate dehy...
متن کاملInfluence of transfection with connexin 26 gene on malignant potential of human hepatoma cells.
We investigated the effect of transfection with connexin (Cx) 26 gene on the malignant potential of PLC/PRF/5 hepatoma cells, observing changes in their morphological features, alpha-fetoprotein (AFP) expression, cell proliferation and apoptosis in vitro, and their tumor growth in vivo. Fluorescence-activated cell sorting (FACS) analysis showed that 10.6% of PLC/PRF/5 hepatoma cells transfected...
متن کاملDownregulation of hepatoma-derived growth factor suppresses the malignant phenotype of U87 human glioma cells.
Hepatoma-derived growth factor (HDGF) has been shown to correlate with increased malignancy of different types of tumors and could be an independent prognostic index for human cancers. We previously found that HDGF is overexpressed in glioma tissues and that its expression level may correlate with the clinical pathological grade. In the present study, we investigated the effects of HDGF downreg...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: Journal of Clinical Pathology
سال: 1973
ISSN: 0021-9746
DOI: 10.1136/jcp.26.5.384